Search for: All records

Generative AI is generating much enthusiasm on potentially advancing biological design in computational biology. In this paper we take a somewhat contrarian view, arguing that a broader and deeper understanding of existing biological sequences is essential before undertaking the design of novel ones. We draw attention, for instance, to current protein function prediction methods which currently face significant limitations due to incomplete data and inherent challenges in defining and measuring function. We propose a “blue sky” vision centered on both comprehensive and precise annotation of existing protein and DNA sequences, aiming to develop a more complete and precise understanding of biological function. By contrasting recent studies that leverage generative AI for biological design with the pressing need for enhanced data annotation, we underscore the importance of prioritizing robust predictive models over premature generative efforts. We advocate for a strategic shift toward thorough sequence annotation and predictive understanding, laying a solid foundation for future advances in biological design. 

Industrial Internet of Things (IIoT) has been shown to be of great value to the deployment of smart industrial environment. With the immense growth of IoT devices, dynamic spectrum sharing is introduced, envisaged as a promising solution to the spectrum shortage in IIoT. Meanwhile, cyber-physical safety issue remains to be a great concern for the reliable operation of IIoT system. In this paper, we consider the dynamic spectrum access in IIoT under a Received Signal Strength (RSS) based adversarial localization attack. We employ a practical and effective power perturbation approach to mitigate the localization threat on the IoT devices and cast the privacy-preserving spectrum sharing problem as a stochastic channel selection game. To address the randomness induced by the power perturbation approach, we develop a two-timescale distributed learning algorithm that converges almost surely to the set of correlated equilibria of the game. The numerical results show the convergence of the algorithm and corroborate that the design of two-timescale learning process effectively alleviates the network throughput degradation brought by the power perturbation procedure.